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. 2010 Feb 15;207(2):273–280. doi: 10.1084/jem.20092029

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© 2010 Satoh-Takayama

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Perturbed development of intestinal CD3⁻GFP⁺ cell subsets in Ncr1^GFP/+ mice that overexpress IL-15 in the intestinal epithelium. (A) NK1.1 versus CD127 expression on gated CD3⁻GFP⁺ cells from small intestinal (SI) LPL and intraepithelial (IEL) compartments. Subset frequencies are indicated. Representative results from one out of six independent experiments are shown. (B) Absolute numbers of total CD3⁻NKp46⁺ cells and CD127/NK1.1 subsets from small intestinal LPLs in WT and IL-15 Tg mice (n = 5–8 mice of each genotype analyzed). Only CD127⁻NK1.1⁺ cells were significantly increased in IL-15 Tg mice. Values are presented as means ± SD. (C) RORγt expression in intestinal CD3⁻NKp46⁺ subsets in WT (bold line) and IL-15 Tg mice (shaded histogram). The dotted line depicts staining of CD3⁻NKp46⁺ cells from Rorc^−/− mice. (D) IL-22 production from intestinal CD3⁻NKp46⁺ subsets in WT and IL-15 Tg mice. Results indicate frequencies from one out of three independent experiments.