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. 2010 Feb 2;133(2):496–511. doi: 10.1093/brain/awp314

Figure 4.

Figure 4

Impact of serotonin innervation in stepping and cylinder tests. Intact forebrain serotonin innervation is critical for recovery in some of the behavioural test paradigms. At 23 weeks post-rAAV injection, all animals in the Les-Sham and TH + GCH1 groups were re-tested in the cylinder and stepping tests. Thereafter, a sub-group of the animals received a unilateral injection of 5,7-DHT into the medial forebrain bundle and were re-assessed behaviourally 2 weeks later. In the cylinder test, the improvement caused by the rAAV-TH + GCH1 delivery was abolished (A), whereas the recovery in stepping performance was maintained (B). Statistics: Repeated measures ANOVA (A) Time, P = 0.027, F(1,6) = 8.51; time × group, P = 0.016, F(1,6) = 11.08; group, P = 0.015, F(1,6) = 11.27. (B) Time, P = 0.64, F(1,6) = 0.25; time × group, P = 0.42, F(1,6) = 0.76; group, P < 0.001, F(1,6) = 420. Post hoc paired t-test (A) TH + GCH1 pre-post P = 0.009; Bonferroni-corrected P = 0.018 (B) TH + GCH1 pre-post P = 0.48. Asterisk indicates significantly different from pre-5,7-DHT lesion.