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. Author manuscript; available in PMC: 2011 Jan 26.
Published in final edited form as: Circulation. 2010 Jan 11;121(3):410. doi: 10.1161/CIRCULATIONAHA.109.889725

Figure 1.

Figure 1

TPM1κ expression in human hearts. A, Real-time RT-PCR quantification of the TPM1α and TPM1κ mRNAs in normal fetal and adult hearts. B, TM protein profile in the normal adult human heart analyzed by Western blotting using striated muscle TM-specific antibody. C, Migration of TM isoforms and TM antibody specificity. D and E, TPM1κ expression and quantification in cardiac total protein lysate from DCM patients using anti-TPM1κ and anti-tubulin antibodies. ** P < 0.01, normal vs. DCM. F and G, TPM1κ protein expression and quantification in cardiac myofibrillar preparations from normal and heart failure patients using anti-TPM1κ and anti-smooth muscle tropomyosin (Sm TM) antibodies. * P < 0.02, normal vs. end-stage HF patients.