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Ongoing release of endocannabinoids modulates GABAergic transmission in mature rat. A: representative traces are averages of responses before and after 10 min application of SR141716. SR141716 enhanced eIPSCs in mature rat, but not in P8 rat. B: in mature rat, SR141716 (2 μM) caused a 43 ± 9% increase in eIPSC amplitude (P < 0.001), but had no significant effect on the eIPSC (only 7 ± 22% increase, P = 0.71) in P8 rat.
