Fig. 6.

Contribution of CD4⁺ and CD8⁺ T cells to GITR-L mediated tumor protection. Average tumor growth following T cell depletion. a Control CT26-∆ECD tumor cells or b GITR-L expressing CT26-Med tumor cells were injected into mice depleted of CD4⁺ T cells, CD8⁺ T cells, or injected with PBS alone and tumor growth monitored. Mice were euthanized when the tumor reached 1.5 cm in diameter. Data are representative of two independent experiments with eight mice per group. **P < 0.01, ***P < 0.001