. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Trends Neurosci. 2010 Feb;33(2):59. doi: 10.1016/j.tins.2009.11.001

Table 2. Mouse phenotypes with Gars alleles.

Gars Genotype	Life Expectancy	Strain Differences	Phenotype	Reference
Gars^Nmf249/⁺ or Gars^P278KY/⁺	6-8 weeks	Outcross to CAST/EiJ extended lifespan but did not alter onset or severity of motor phenotype	Sensory and motor deficits Abnormal NMJ morphology Impaired nerve impulse transmission Reduced NCVs Loss of large diameter peripheral axons	Seburn et al. 2006
Gars^{Nmf249/Nmf249}	Embryonic lethal	NA	NA	Seburn et al. 2006
Gars^XM256/⁺	Normal lifespan	NA	Reduced GARS RNA levels Normal NMJ morphology Normal NCVs	Seburn et al. 2006
Gars^XM256/XM256	Embryonic lethal	NA	NA	Seburn et al. 2006
Gars^Nmf249/XM256	Embryonic lethal	NA	NA	Seburn et al. 2006
Gars^C201R/⁺	Normal lifespan	Motor phenotype is more severe on B6 background than on C3H	Decreased grip strength Poor skilled motor function Increased total GARS protein at p15 Reduction in large diameter axons in sciatic nerve	Achilli et al. 2009
Gars^C201R/C201R	17 days (maximum)	Maximum life expectancy 15 days on C3H background	Reduced weight and viability Impaired limb movement	Achilli et al. 2009
Gars^C201R/XM256	Embryonic lethal	NA	NA	Achilli et al. 2009