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. Author manuscript; available in PMC: 2010 Feb 20.
Published in final edited form as: Virology. 2009 Dec 6;397(2):299–310. doi: 10.1016/j.virol.2009.11.023

Fig. 1.

Fig. 1

Schematic representation of the Epstein-Barr virus nuclear antigen 2 (EBNA2). EBNA2 of the standard B95.8 strain (accession number: AJ507799) of EBV consists of 487 amino acids (aa) present in a A-type viruses. The N-terminal dimerisation domain (“Dim”) is located next to a poly-proline stretch (“Pro”). The variable region (“variable”) differs between the A-type viruses and B-type viruses. B-type viruses have a reduced in vitro transformation potential. The binding site for RBPJκ (“RBPJκ”) is located around a Trp-Trp-Pro motif at aa 323-325. The adjacent Arginine-Glycine repeat (“ArgGly”) between aa 339-354 confers binding to the survival of motor neurons (SMN) protein and represents the second nuclear localization signal (“NLS”) in addition to the canonical NLS found at the extreme C-terminus between aa 468-487. The C-terminal acidic transactivation domain (“TAD”) between aa 424-468 interacts with various basal transcription factors.