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Menthol-induced cold hypersensitivity is not inhibited by BEL. A. Intraplantar administration of menthol (3-25 mg) induced a time- and dose-dependent reduction in ipsilateral paw withdrawal latency in freely-moving rats. B. Prior administration of BEL (30-300 μg) had no effect on the cold hypersensitivity evoked by 25 mg menthol. Data show mean ± SEM for 6 rats/group. * p < 0.05, *** p < 0.001 vs vehicle.
