Table 1.
Genes with significant mutation clusters (Probability < 0.01)
| Gene | Cluster size |
Cluster positions |
Number of mutations in cluster |
Cumulative cluster probability* |
|---|---|---|---|---|
| KRAS (188 aa) | 2 | 12-13 | 131 | 1.47E-234 |
| BRAF (766 aa) | 1 | 600-600 | 60 | 2.02E-157 |
| TP53 (393 aa) | 155 | 132-286 | 326 | 3.07E-101 |
| NRAS (189 aa) | 1 | 61-61 | 33 | 7.11E-62 |
| PIK3CA (1068 aa) | 5 | 542-546 | 27 | 7.09E-46 |
| CTNNB1 (781 aa) | 13 | 33-45 | 12 | 8.54E-19 |
| ERBB2 (1255 aa) | 1 | 776-776 | 2 | 7.97e-4 |
| HRAS (189 aa) | 1 | 61-61 | 4 | 2.06E-06 |
| PTEN (403 aa) | 63 | 111-173 | 8 | 5.50E-05 |
| MAP2K7 (419 aa) | 1 | 162-162 | 2 | 0.002386 |
| LRRK2 (2534 aa) | 4 | 1723-1726 | 2 | 0.003547 |
*: only most significant cluster per gene is listed