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. 2010 Jan 19;11:6. doi: 10.1186/1471-2202-11-6

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Copyright ©2010 Nishino et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Function and evolution of Ci-GlyR. (A, B) Effect of gene suppression on larval swimming by morpholino injection into developing eggs. (A) Antisense morpholino disrupts alternating swimming in a similar manner to strychnine. (B) 5-base mismatched control morpholino is without effect on swimming, larvae are capable of normal alternating swimming (Supp. Video 2). (C) The phylogeny of Ci-GlyR compared to other members of the Cys-loop superfamily of ligand gated chloride channels (Ci-GlyR is indicated in the box). Hs: H. sapiens, Zf: D. rerio (zebrafish), Ci: C intestinalis, Ce: C. elegans, Dm: D. melanogaster, Sp: S. purpuratus (sea urchin).