Figure 3.
The effect of S. mansoni infection on the development of cerebral malaria in ICR mice. Mice infected with 5 × 104 PbA-infected erythrocytes (A), 5 × 104 PbA-infected erythrocytes, seven weeks after injection of 50 S. mansoni cercariae (B), or 5 × 104 PbA-infected erythrocytes, seven weeks after injection of 100 S. mansoni cercariae (C). Each line represents one mouse; D notes mouse death. Co-infection of mice with 100 cercariae caused a significant reduction in cerebral malaria (p < 0.0001, t-test). Shaded areas denote the period of CM susceptibility and death.