Table 2.

List of 61 known genes significantly up- and down-regulated in > 60 ml prostates compared to <60 ml prostates (fold change ≤0.5 or >2 in SAM analysis)

Down-regulated genes		Up-regulated genes
Gene Symbol	FC	Gene Symbol	FC	Gene Symbol	FC
GPR34	0.12	TMEM16A	2.00	RGS1	2.34
HBG2	0.23	LILRB2	2.02	LMAN2	2.44
HBD	0.26	LRAP	2.02	C1S	2.46
HBA2	0.26	FKBP1A	2.03	NGFR	2.47
SERPINA9	0.30	PAEP	2.04	TGFBR2	2.51
PPEF2	0.32	ANGPT2	2.04	ZFP36	2.58
MAGEA11	0.34	TACSTD1	2.09	DPP4	2.61
HBG1	0.36	CHST9	2.12	GSTT2	2.77
NPHS1	0.36	MBL2	2.12	NPPC	2.90
PMFBP1	0.36	MEST	2.14	COL17A1	3.33
HSPA1B	0.37	PDE4B	2.14	IL1F7	3.39
ADH4	0.38	TMEFF2	2.14	PIP5K2A	3.58
BPIL2	0.43	RTN1	2.14	NLGN4Y	3.99
MAB21L2	0.43	DUSP6	2.15	NODAL	3.99
PCSK9	0.43	PRSS8	2.15	ZNF165	4.20
ADRA1B	0.45	KLK11	2.18	CITED1	4.69
DYRK3	0.46	AMD1	2.20	CD33	6.38
ADAM29	0.48	CYP4X1	2.25
PTHR2	0.49	HOXB13	2.31
CHRDL2	0.49	CHST7	2.31
FTHL17	0.50	FZD1	2.34
SIX5	0.50	AHNAK	2.34

FC, fold change between prostates >60ml and <60ml