Table 4.

List of genes significantly up and down-regulated in > 60 ml prostates compared to <60 ml prostates for six separately explored pathways (list limited to genes with fold change <0.7 or >1.3 in SAM analysis).

Gene Symbol	Fold Change (prostates >60ml vs <60ml)	Gene Symbol	Fold change (prostates >60ml vs <60ml)	Gene Symbol	Fold Change (prostates >60ml vs <60ml)	Gene Symbol	Fold Change (prostates >60ml vs <60ml)
Androgen regulated genes		Cell cycle genes		Apoptosis genes		Growth factors genes
ARSD	1.31	ORC2L	1.32	BIRC3	1.31	IGF2R	1.34
TPD52	1.48	HDAC1	1.32	SFRS2IP	1.31	ERBB3	1.35
IQGAP2	1.70	CCNH	1.32	CASP3	1.31	KLK3	1.35
CEBPD	1.70	RB1	1.32	BID	1.35	IGFBP2	1.49
LCP1	1.83	CDK4	1.32	JUN	1.35	VEGF	1.55
		ABL1	1.35	TNFRSF1A	1.37
Genes of hypertrophy		E2F6	1.35	TNFSF10	1.39	Inflammation genes
		BUB3	1.36	TP53	1.39	IL4	0.58
IL1A	0.67	ORC5L	1.38	BCL2A1	1.42	CD86	0.62
IL1R1	1.34	MAD2L2	1.38	CASP4	1.47	CCR5	0.66
ADAM10	1.41	SMAD4	1.43	TNFRSF1B	1.47	IL5RA	0.69
JUND	1.51	PRKDC	1.46	NFKB1	1.50	COL3A1	1.33
VEGF	1.55	MCM2	1.50	CASP1	1.53	LCK	1.36
CYR61	1.61	TFDP1	1.51	RIPK1	1.66	IL2RB	1.37
DUSP14	1.65	PCNA	1.53	MAP2K4	1.83	TLR2	1.40
TCF8	1.86	CDC45L	1.72	MYC	2.37	CXCR4	1.44
ATF3	2.16	ORC1L	2.18			TLR3	1.48
						TLR1	1.53