FIG. 1.

(A) Schematic representation of the cortical injury device. (B) Illustration of the scaled indentor tips and their use in histological sampling. The tip diameter and indentation depth increase in proportion to increases in brain dimension with age, from youngest (left) to oldest (right), as described in the text. Histological samples were taken at the 0%, 25%, 50%, 75%, and 100% regions of tissue under the indentor tip for each subject (reprinted with permission from the Journal of Neurosurgery, www.thejns-net.org).