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Lactate dehydrogenase (LDH) release in primary mouse cortical neurons after 8 h of hypoxia, followed by 16 h of reoxygenation. Neurotoxicity was significantly ameliorated by treatment with recombinant human tissue inhibitor of metalloproteinase—1 (TIMP-1) at 500 nM concentrations. *p < 0.05; n = 4 independent experiments performed in duplicate.
