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Brain injury after focal cerebral ischemia. (A) Ischemic lesion volumes at 24 h post-ischemia were significantly reduced in tissue inhibitor of metalloproteinase—1 (TIMP-1) transgenic mice compared with wild-type mice after 2 h of transient ischemia. *p < 0.05; n = 7 per group. (B) At 24 h after a 2-h transient ischemic insult, blood-brain barrier damage was significantly reduced by overexpression of TIMP-1, as measured by Evans blue dye leakage. *p < 0.05; n = 8 per group.
