Table 3.
Neuropsychological Assessment of Children with and without an APOE ɛ4 Allele across Time
| |
Baseline |
3-month |
12-month |
|||
|---|---|---|---|---|---|---|
| Variable | ɛ4 group | Non-ɛ4 group | ɛ4 group | Non-ɛ4 group | ɛ4 group | Non-ɛ4 group |
| WASI | ||||||
| Full-Scale IQ | 105.04 (12.63) | 101.86 (13.55) | — | — | 106.89 (12.04) | 103.59 (14.01) |
| WRAT-3 | ||||||
| Reading | 104.04 (9.48) | 103.73 (14.18) | — | — | 105.00 (9.87) | 104.35 (13.62) |
| Spelling | 101.21 (11.46) | 102.93 (14.80) | — | — | 102.46 (10.63) | 102.80 (15.82) |
| Arithmetic | 104.29 (13.94) | 102.77 (14.56) | — | — | 101.36 (12.45) | 102.33 (16.34) |
| CVLT-C | ||||||
| Total Words T score | 50.19 (10.42) | 49.83 (9.09) | 55.41 (9.94) | 54.97 (10.53) | 52.22 (9.13) | 53.34 (10.85) |
| VMIa | 99.19 (14.10) | 92.81 (11.82) | 95.26 (14.38) | 89.57 (10.69) | 96.78 (12.95) | 91.19 (11.95) |
| CANTAB | ||||||
| MST: Latency (msec) | 823.18 (337.92) | 739.39 (189.98) | 724.95 (178.22) | 735.05 (181.57) | 694.13 (182.52) | 737.54 (295.97) |
| PRM: Number correct | 21.04 (2.66) | 20.31 (3.03) | 22.04 (1.76) | 22.17 (1.86) | 22.19 (1.72) | 21.39 (2.68) |
| SOC: Problems solved in minimum moves | 7.50 (1.68) | 7.41 (2.10) | 8.65 (1.92) | 8.36 (1.98) | 8.62 (2.02) | 8.83 (1.94) |
| SWM: Between errors | 35.04 (19.83) | 32.14 (16.88) | 27.04 (19.58) | 29.34 (18.89) | 28.12 (18.94) | 26.43 (18.23) |
a
p < 0.05.
Data represent means (with SD). WASI, Wechsler Abbreviated Scale of Intelligence; WRAT-3, Wide Range Achievement Test–3rd edition; CVLT-C, California Verbal Learning Test–Children's Version; VMI, the Developmental Test of Visual-Motor Integration; CANTAB, Cambridge Neuropsychological Test Automated Battery; MST, Motor Screening Test; PRM, Pattern Recognition Memory; SOC, Stockings of Cambridge; SWM, Spatial Working Memory.