Skip to main content
. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Clin Cancer Res. 2010 Feb 9;16(4):1119. doi: 10.1158/1078-0432.CCR-09-2642

Figure 1. miR-34 is downregulated in EOC and associated with metastatic clinical stage.

Figure 1

A. qRT-PCR analysis reveals significantly reduced miR-34a, miR-34b* and miR-34c expression in a panel of EOC samples (open circles, n=83) relative to normal OSE samples (open triangles, n=6) (p<0.0001, p=0.0172 and p=0.0022, respectively). B. Ovarian cancer stage was determined by surgical evaluation during cryoreduction/debulking surgery. miR-34a, miR-34b* and miR-34c expression is shown for stage 3 (n=46, open triangles) and stage 4 (n= 18, open circles) tumors. miR-34b* and miR-34c expression is significantly decreased in stage 4 (distant metastasis) compared to stage 3 (localized to peritoneum) (p=0.0171 and p=0.0029, respectively). C. Adenocarcinomas (serous type, n=26) and wild type OSE samples (n=6) were analyzed for p53 mutational status by direct sequencing and correlated with miR-34 expression. While both p53 wild type (WT, circles) and p53 mutant (Mut, squares) EOC samples show significantly reduced miR-34a expression compared to wild type OSE (N, triangles), EOC samples with mutant p53 demonstrate most downregulated expression for miR-34a, miR-34b* and miR-34c (p=0.0012, p=0.0285 and p=0.0216, respectively). Error bars represent standard deviation.