Table 2B. Clinical and Pathological Characteristics of Patients with Histologically Unrelated Second Primary Tumors.

Patient No.	HPV status	Tobacco History	Pack- Years (Cigarette use only)	Primary Tumor Site	T Class	N Class	Disease Recurrence Event (LR, DM or SP)	Site of Disease Recurrence Event	Patient status at last follow- up (in reference to SCCOP)
31	Positive	Never	0	Oropharynx^	2	3	SP	Prostate*	No evidence of disease
32	Positive	Former cigarette; quit 17 yr prior	20	Tonsil	1	2b	SP	Lung (B-cell lymphoma)*	No evidence of disease
33	Negative	Former cigarette; quit 12 yr prior	70	Oropharynx^	3	1	SP	Lung (adenocarcinoma)*	Dead without disease

LR, local/regional recurrence; DM, distant metastasis; SP, second primary tumor; yr, year; SCCOP, squamous cell carcinoma of the oropharynx

^*SP tumor unrelated to original SCCOP based on location (patient 31) or tumor cell histology (patients 32 and 33). Patients 31 and 32 are alive with no evidence of SCCOP recurrence after eight years and 1.5 years of follow-up, respectively. Patient 33 died from the lung adenocarcinoma after four years without evidence of SCCOP recurrence. These three patients were censored at the last follow-up time for statistical analysis of time-to-disease recurrence.

^{^}Tumor site within oropharynx unspecified