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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Clin Cancer Res. 2010 Feb 9;16(4):1179. doi: 10.1158/1078-0432.CCR-09-1787

Figure 1. Relationship between ER status and cyclin E in breast cancer.

Figure 1

Breast cancer specimens from 395 patients were assessed for ER and cyclin E expression. (A) Overall survival (OS) was higher in patients with ER-positive (n-234) tumors (p=0.0029). (B) Patients with ER-positive tumors were stratified by LMW cyclin E expression. Patients with high LMW cyclin E had markedly decreased OS (median OS = 3.25 yrs) compared to those with low levels of LMW cyclin E (median OS not reached) (p<0.0001). (C) The relationship between OS, ER and LMW cyclin E was maintained in postmenopausal patients (p<0.001).