Table 3. Study participants according to categories of the Revised Bethesda Guidelines (Classified according to the ‘dominant’ criterion; that is, one patient can fulfil more than one of the criteria).

Revised Bethesda Guidelines 2004	Number of patients	Proportion (%)
1. CRC diagnosed in a patient <50 years	20	23.0
2. Presence of metachronous, synchronous colorectal or other Lynch-relateda tumours, regardless of age	14	16.1
3. CRC with MSI-H phenotypeb diagnosed before 60 years of age	21	24.1
4. Patient with CRC and a first-degree relative with a LS-related tumour, with one cancer diagnosed before 50 years of age	12	13.8
5. Patient with CRC with two or more first- or second-degree relatives with a LS-related tumour, regardless of age	20	23.0
Total	336	100.0

Abbreviations: CRC=colorectal cancer; LS=Lynch syndrome; MSI-H=microsatellite instability-high.

^aLynch syndrome-related tumours: colorectal, endometrial, stomach, ovarian, pancreas, ureters, renal pelvis, biliary tract and brain tumours, sebaceous gland adenomas and keratoacanthomas, and carcinoma of the small bowel.

^bLymfocyte-infiltrating tumours, low grade or undifferentiated, Crohn's-like lymphocyte infiltration, the presence of mucin or signet cells in the tumours, and ‘cribriform growth pattern’.