Skip to main content
. 2009 May 1;42(2):149–160. doi: 10.1165/rcmb.2008-0287OC

Figure 6.

Figure 6.

Macrophages in the alveolar regions of infant mice. Pregnant bi-TG and control dams received doxycycline in drinking water from E0 or E15 until the pups were killed at PN7. (A–H) Immunohistochemical staining for macrophages. More macrophages were seen in both groups of bi-TG offspring of control dams (E and G) and in bi-TG offspring of bi-TG dam given doxycycline from E15 (H) than in bi-TG pups of bi-TG dams given doxycycline from E0 (F) and in all groups of control pups (A–D). (I) Macrophage counts in the lungs of offspring. Maternal hIL-1β production preceding fetal hIL-1β production inhibited infiltration of the alveoli and alveolar walls of bi-TG pups with macrophages. Open bars, control pups; gray bars, bi-TG pups; n ≥ 4 in each group; *P ≤ 0.05, ***P ≤ 0.001, bi-TG pups versus control pups; †††P ≤ 0.001, compared with bi-TG pups of bi-TG dam given doxycycline from E0. Scale bar, 100 μm.