Table 3.

Effects of mph1, rev3, srs2, and mec3 deletions on the accumulation of chromosomal rearrangements in a new GCR strain background (RDKY6678) that is prone to duplication-mediated rearrangements^a

Relevant genotype	Strain	GCR rate (Canr 5-FOAr) (× 10−8)b	95% CIc (Canr 5-FOAr) (× 10−8)	Fold increase over wild-type level
Wild type	RDKY6678	2d		1
mph1	RDKY6795	18	10–31	9
rev3	KHSY3110	13	8–20	7
rev3 mph1	KHSY3056	334	237–389	167
rev3 mph1 srs2	KHSY3123	57	41–67	29
srs2	KHSY3067	31	21–54	16
mph1 srs2	KHSY3101	40	32–61	20
mec3	KHSY3065	44	30–59	22
mph1 mec3	KHSY3042	43	30–98	22
mph1 mec3 srs2	KHSY3126	142	116–191	71

^aSee reference 34.

^b5-FOA, 5-fluoroorotic acid.

^cNinety-five percent confidence intervals (CIs) were calculated according to the method of Nair (26), with nonoverlapping confidence intervals indicating statistically significant differences (α < 0.05) between median GCR rates.

^dGCR rate from reference 34.