Table 9.
entry | aryl halide | electrophile | loading (%) | T1 (°C)b | T2 (°C)b | product | yield (%)c |
---|---|---|---|---|---|---|---|
1d | 0.1 | 100 | 25 | 89 | |||
2 | 0.1 | 100 | 25 | 51 | |||
3d | 0.1 | 100 | 50 | 74 | |||
4 | Boc2 | 0.1 | 100 | 80 | 75 | ||
5d | 0.1 | 100 | 50 | 82 | |||
6d | 0.1 | 100 | 50 | 94 | |||
7 | Boc2 | 0.1 | 100 | 80 | 68 | ||
8 | 0.1 | 90 | 25 | 75 |
Reactions conducted with 1:1 ratio of metal to ligand.
Temperature of bath.
Isolated yield after purification by flash column chromatography.
1 equiv of Et3N was added.