TABLE 1.
Demographic and Characteristics of Pulmonary Function in Children with Sickle Cell Disease With Normal, Restricted, or Obstructed Pulmonary Function
| In all subjects |
|||
|---|---|---|---|
| Normal (n = 77) | Restrictive (n = 13) | Obstructive (n = 13) | |
| Mean age at PFT (years) | 11.9 | 12.4 | 12.9 |
| Mean follow-up (years) | 3.7, Median = 3.1 (0.8–9.6) | 3.8, Median = 3.0 (0.6–7.9) | 3.9, Median = 2.6 (1.8–8.0) |
| Male (%) | 44.2% | 53.8% | 38.5% |
| Hemoglobin SS (%) | 77.6% | 58.3% | 61.5% |
| FEV1/FVC (%) | 88.7 | 88.3 | 75.2 |
| FEV1 (percent predicted) | 92.1 | 68.5 | 72.1 |
| FVC (percent predicted) | 91.3 | 66.6 | 84.2 |
| TLC (percent predicted) | 95.5 | 72.6 | 94.8 |
| Asthma diagnosis (%) | 53.2% | 38.5% | 76.9% |
FEV1/FVC, forced expiratory volume in 1 sec/ forced vital capacity; FEV1, forced expiratory volume in 1 sec; TLC, total lung capacity.