Table 3.

mRNA expression of MMPs, ADAMTS, and TIMPs in nodule tissue (active disease) and cord tissue (end-stage disease) from patients with Dupuytren's disease (n = 19) as compared to control palmar fascia from patients with carpal tunnel syndrome (n = 19). Data from Johnston et al. (2007). Only proteins that showed statistically significant differences between groups are shown

	Elevated	Decreased
Dupuytren's nodule compared to control	MMP-1, -2, -7, -11, -13, -14, -15, -16, -17, -19, -21 ADAMTS-2, -3, -4, -5, -9, -14, -16, -18 TIMP-1	MMP-3 ADAMTS-1, -6, -8, -19, -20 TIMP-2, -3, -4
Dupuytren's cord compared to control	MMP-2, -7, -11, -13, -16 ADAMTS-3, -12, -18	MMP-3
Dupuytren's nodule compared to cord	MMP-2, -11, -13, -14, -15, -16, -17, -19, -28 ADAMTS-2, -4, -5, -12, -14 TIMP-1	MMP-3, -8 ADAMTS-1, -6, -8 TIMP-2, -4