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. 2009 Aug 24;159(1):93–101. doi: 10.1111/j.1476-5381.2009.00371.x

Figure 2.

Figure 2

Effects of compounds on QTc (Fredericia's correction) in guinea-pig isolated hearts. Preparations were superfused with Krebs–Henseleit solution (baseline) followed by Krebs–Henseleit solution (control group, n= 10), Dox (30 µM, n= 6), Dex (30 µM, n= 6), Dox (30 µM) + Dex (3, 10 or 30 µM, n= 6 per concentration), Mox (100 µM, n= 4) or Dex (30 µM) + Mox (100 µM, n= 4). Mean values over the 45 min treatment period are shown. Data are expressed as percentage variations from baseline + SEM. **P < 0.01 versus time-matched control group (anova followed by Bonferroni's test performed on absolute variations from baseline). !P < 0.05 and !!P < 0.01 versus time-matched Dox 30 µM group (anova followed by Bonferroni's test performed on absolute variations from baseline). Dex, dexrazoxane; Dox, doxorubicin; Mox, moxifloxacin.