Figure 4.
Cannabidiol-induced antidepressant-like effects were not associated with alterations in hippocampal BDNF levels. Mice (7–8 per group) received i.p. injection of cannabidiol (CBD, 30 mg·kg−1) or imipramine (IMP, 30 mg·kg−1) and 30 min later were submitted to the forced swim test (left graph). Immediately after, the animals were killed, their hippocampi removed and processed for BDNF measurements (right graph). Data represent the mean ± SEM. * indicates P < 0.05 compared with vehicle group (anova followed by Duncan).