Table 1.
Cannabigerol stimulates [35S]GTPγS binding to brain membranes obtained from MF1, CB1+/+ C57BL/6J and CB1−/− C57BL/6J mice
Mouse strain | Mean EC50 (95% CL) | Mean Emax (95% CL) | n |
---|---|---|---|
MF1 | 0.2 nM (0.006 and 9.0 nM) | 15.5% (8.5 and 22.5%) | 7 to 20 |
CB1+/+ C57BL/6J | 0.04 nM (0.002 and 0.8 nM) | 17.0% (10.4 and 23.7%) | 8 |
CB1−/− C57BL/6J | 0.17 nM (0.01 and 2.8 nM) | 11.4% (6.6 and 16.2%) | 8 |
Mean EC50 and Emax values were calculated from data obtained with cannabigerol concentrations of up to 10 nM.
CL, confidence limits.