Table 2.
Effects of denervation on the pEC50 for phenylephrine with and without desmethylimipramine (DMI, 30 nM), and for methoxamine and clonidine
|
Phenylephrine |
Phenylephrine+DMI |
Methoxamine |
Clonidine |
|
|---|---|---|---|---|
| pEC50 | pEC50 | pEC50 | pEC50 | |
| Two weeks control (n= 6) | 5.76 ± 0.10 | 6.58 (6.38–6.63) | 5.92 ± 0.05 | 7.08 (6.92–7.13) |
| Two weeks denervated (n= 6) | 7.05 ± 0.09 | 7.03 (7.00–7.07) | 6.29 ± 0.04 | 7.85 (7.60–8.14) |
| P | <0.01* | <0.01* | <0.01* | <0.01* |
| Seven weeks control (n= 6) | 5.81 ± 0.10 | 6.74 ± 0.10 | 6.25 ± 0.08 | 7.33 ± 0.12 |
| Seven weeks denervated (n= 6) | 6.98 ± 0.06 | 6.94 ± 0.06 | 6.50 ± 0.16 | 7.73 ± 0.15 |
| P | <0.01* | 0.13 | 0.20 | 0.08 |
The 2 weeks data for phenylephrine in the presence of desmethylimipramine and for clonidine are presented as medians and interquartile ranges (in parentheses). All other data are presented as means ± standard errors. P values for comparisons between control and denervated arteries were derived using either unpaired t-tests or Mann–Whitney U-tests, and
*
indicates significant differences.