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Effect of increasing [K]o to 25 mM on isoprenaline and bradykinin-induced relaxation of rings pre-constricted with 5-HT or 5-HT in the presence of SB216641. In 5-HT constricted rings relaxation to isoprenaline and bradykinin was unaffected by high [K]o, but the relaxation in the presence of SB216641 was reduced by approximately 40–50%. Results are the means ± SEM from four to six experiments (number of arteries from different animals).
