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. 2009 Dec 10;159(1):201–211. doi: 10.1111/j.1476-5381.2009.00522.x

Figure 1.

Figure 1

Effect of pretreatment with repeated cocaine (20 mg·kg−1, i.p. twice daily separated by 8 h for 3 days) finishing 1 or 4 days before 3,4-methylenedioxymethamphetamine (MDMA) (20 mg·kg−1, i.p., two injections separated 3 h) on (A) rectal temperature immediately following MDMA administration and (B) [3H]WIN 35 428 binding. Data shown as mean ± SEM, n= 5 − 11. There were no differences between the data obtained from saline controls pretreated 1 or 4 days earlier with cocaine and therefore data were grouped. (A) The MDMA-induced increase in rectal temperature (F1,11= 54.79; P < 0.001) was not modified by pretreatment with cocaine 1 day (F1,13= 0.97; P= 0.32, n.s.) or 4 days (F1,11= 0.93; P= 0.33, n.s.) before. Cocaine pretreatment did not modify the temperature of saline-treated animals (F1,15= 3.64; P= 0.06, n.s.). Two-way analysis of variance (anova). (B) Different from saline: *P < 0.001; different from MDMA: ΔP < 0.001; different from cocaine + MDMA 1 day later: δP < 0.001; different from cocaine + saline: fP < 0.05. One-way anova followed by Newman–Keuls test.