Figure 2.

Effect of co-administration of NPC 15437 (1 mg·kg⁻¹, i.p.) and cocaine (20 mg·kg⁻¹, i.p. twice daily separated by 8 h for 3 days) finishing 4 days before 3,4-methylenedioxymethamphetamine (MDMA) (20 mg·kg⁻¹, i.p., two injections separated 3 h) on striatal (A) [³H]WIN 35 428 binding and (B) dopamine (DA) concentration, 7 days later. Data shown as mean ± SEM, n= 6 − 11. Different from saline *P < 0.001; different from MDMA: ^ΔP < 0.001; different from cocaine + MDMA: ^δP < 0.05, ^δδδP < 0.001; different from NPC (during cocaine treatment + withdrawal) + cocaine + MDMA: ^fP < 0.01, ^ffP < 0.001. One-way anova followed by Newman–Keuls test.