Figure 3.

Effect of repeated cocaine (20 mg·kg⁻¹, i.p. twice daily separated by 8 h for 3 days) on striatal plasma membrane (A) and endosome (B) [³H]WIN 35 428 binding 1 or 4 days later. A group of animals were co-administered NPC 15437 (1 mg·kg⁻¹, i.p.) with cocaine and twice daily during the 3-day withdrawal. Data shown as mean ± SEM, n= 7 − 10. Different from saline: *P < 0.01; different from cocaine 1 day before: ^fP < 0.05, ^ffP < 0.01; different from cocaine only 4 days before: ^δP < 0.05. One-way anova followed by Newman–Keuls test.