Table 1.
Treatment | DA | DOPAC | HVA | l-DOPA |
---|---|---|---|---|
Saline | 9828 ± 251 | 767 ± 19 | 853 ± 51 | 1386 ± 44 |
MDMA | 5312 ± 392*** | 330 ± 58*** | 578 ± 49*** | 920 ± 48*** |
Cocaine + MDMA 1 day later | 5074 ± 517*** | 365 ± 59*** | 572 ± 25*** | 749 ± 66*** |
Cocaine + MDMA 4 days later | 8342 ± 394*, ΔΔ, δδ, ff | 532 ± 39***, ΔΔ, δδ, ff | 758 ± 61δ, Δ, f | 1137 ± 64**, Δ, δδ, ff |
Cocaine | 10 259 ± 274 | 717 ± 29 | 931 ± 46 | 1455 ± 54 |
Data represented in ng·(g tissue)−1 and are means ± SEM; n= 5 − 11. There were no differences between the data obtained from saline controls pretreated 1 or 4 days earlier with cocaine and therefore data were grouped. There were no differences between the data obtained from saline controls pretreated 1 or 4 days earlier with cocaine and therefore data were grouped.
Different from saline:
P < 0.05,
P < 0.01,
P < 0.001; different from MDMA:
P < 0.01,
P < 0.001; different from cocaine + MDMA 1 day later:
P < 0.01,
P < 0.001; different from cocaine + saline:
P < 0.05,
P < 0.001. One-way anova followed by Newman–Keuls test.