Table 1.

Effect of pretreatment with repeated cocaine (20 mg·kg^-1, i.p. twice daily separated by 8 h for 3 days) finishing 1 or 4 days before 3,4-methylenedioxymethamphetamine (MDMA) (20 mg·kg^-1, i.p., two injections separated 3 h) on dopamine (DA), DOPAC, HVA and l-DOPA concentration 7 days later

Treatment	DA	DOPAC	HVA	l-DOPA
Saline	9828 ± 251	767 ± 19	853 ± 51	1386 ± 44
MDMA	5312 ± 392***	330 ± 58***	578 ± 49***	920 ± 48***
Cocaine + MDMA 1 day later	5074 ± 517***	365 ± 59***	572 ± 25***	749 ± 66***
Cocaine + MDMA 4 days later	8342 ± 394*, ΔΔ, δδ, ff	532 ± 39***, ΔΔ, δδ, ff	758 ± 61δ, Δ, f	1137 ± 64**, Δ, δδ, ff
Cocaine	10 259 ± 274	717 ± 29	931 ± 46	1455 ± 54

Data represented in ng·(g tissue)⁻¹ and are means ± SEM; n= 5 − 11. There were no differences between the data obtained from saline controls pretreated 1 or 4 days earlier with cocaine and therefore data were grouped. There were no differences between the data obtained from saline controls pretreated 1 or 4 days earlier with cocaine and therefore data were grouped.

Different from saline:

^*P < 0.05,

^**P < 0.01,

^***P < 0.001; different from MDMA:

^ΔP < 0.01,

^ΔΔP < 0.001; different from cocaine + MDMA 1 day later:

^δP < 0.01,

^δδP < 0.001; different from cocaine + saline:

^fP < 0.05,

^ffP < 0.001. One-way anova followed by Newman–Keuls test.