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NO induces mitochondrial fission and S-nitrosylation of Drp1. (A) Cortical neurons transfected with mito-DsRed2 were exposed to 200 μM SNOC. Fluorescent images show mitochondrial morphology before and 1 hour after SNOC. (B) SNOC induced mitochondrial fragmentation in a dose-dependent manner. Values are means + SEM (n = 3, *P < 0.05). (C) Cortical neurons were exposed to SNOC or decayed (old) SNOC for <15 min and subjected to biotin-switch assay.
