Figure 5.

Thy1α6 transgenic mice have increased sensitivity to the ataxic effects of muscimol. The fixed speed rotarod measured the ataxic effects of 0.75, 1.0, or 1.5 mg/kg muscimol in Thy1α6 transgenic mice (white squares) and C57BL/6 WT controls (black squares). Muscimol impaired the performance of neither mouse line at the dose of 0.75 mg/kg (a, b). Because of significant differences between genders at the two higher doses, data were split between females and males. At those doses and between both genders, Thy1α6 mice were more sensitive to muscimol than controls ((c), females, 1.0 mg/kg, p<0.001; (d), males 1.0 mg/kg, p<0.001; (e), females, 1.5 mg/kg, p<0.05; (f), males, 1.5 mg/kg, p<0.05) (repeated measures ANOVA). n=6 per gender and genotype.