Figure 6.

Thy1α6 transgenic mice have increased sensitivity to the locomotor stimulating effect of muscimol in the open field test. Male Thy1α6 transgenic and C57BL/6 WT control mice were treated with saline or 0.75 mg/kg muscimol 30 min before being transferred to an open arena. Total locomotor activity (a), time spent in the periphery of the arena (b), and the number of rears (c) were determined for 5 min. Locomotor activity was increased by muscimol in Thy1α6 mice as compared with saline-treated mice (p<0.001) and muscimol-treated WT mice (p<0.001), especially in the periphery of the arena. Muscimol treatment reduced the number of rears in Thy1α6 mice (p<0.01). (Two-way ANOVA followed by Newman–Keuls post hoc test). n=10 males per genotype and treatment.