Table 1.
Permeability Coefficient and Lag Time of Corticosterone Transport across HEM and Permeation Enhancement Factor.
| HEM Treatment | Permeability coefficient of HEM for CS (10−7 cm/s)a | Lag Time in Minutes | Enhancement Factorb |
|---|---|---|---|
| PBS | 2.1 ± 0.7 | 47 ± 15 | NA |
| Ethanol (EtOH) | 1.7 ± 0.5 | 56 ± 4 | NA |
| DoP/EtOH | 33 ± 11 | 48 ± 16 | 23 ± 5 |
| OS/EtOH | 6.5 ± 5.7 | 47 ± 14 | 2.5 ± 0.9 |
| IPM/EtOH | 4 ± 1 | 46 ± 14 | 3 ± 1 |
| AZ/EtOH | 11 ± 2 | 58 ± 17 | 8 ± 1 |
| PADO/EtOH | 4 ± 2 | 39 ± 11 | 3 ± 2 |
| UD/EtOH | 19 ± 3 | 58 ± 12 | 14 ± 4 |
| OA/EtOH | 10 ± 4 | 49 ± 6 | 7 ± 2 |
| PHE/EtOHd | 2.2 ± 0.6 | NA | 1.5 ± 0.3c |
| OP/EtOHd | 1.7 ± 0.1 | NA | 1.2 ± 0.2c |
| OC/EtOHd | 1.4 ± 0.3 | NA | 1.0 ± 0.3c |
a
Mean ± SD (n ≥ 3).
b
Calculated using equation (3).
c
Enhancement factor not significantly different from unity, possibly due to enhancer depletion and the relatively low enhancer Koct.
d
Enhancers examined in the HEM barrier recovery study