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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Exp Eye Res. 2009 Aug 12;89(6):934–941. doi: 10.1016/j.exer.2009.08.001

Table 1.

Summary of the experiments.a

Permeant Protocol Delivery and enhancing
mechanism		 Purpose
Dextran 2 mA anodal or cathodal
iontophoresis for 10 s		 Electroosmosis and electro-
permeabilization		 Determine the effect of
electroosmosis
Dextran 0.5 mA anodal iontophoresis for 1
min		 Electroosmosis and electro-
permeabilization		 Determine the effect of electric
current
Dextran,
GAPDH siRNA		 Passive delivery for 1 min Diffusion, effect of the solution,
device physical effect		 Passive control
GAPDH siRNA 0.5 mA anodal or cathodal
iontophoresis for 1 min		 Electrophoresis, electroosmosis,
and electro-permeabilization		 Determine the effect of
electrophoresis; examine the
delivery over 24 hr
GAPDH siRNA 20 V (8 pulses, 50 ms length, 1 s
interval) anodal or cathodal
electroporation		 Electroporation and diffusion Examine the delivery over 24 hr;
compare electroporation with
iontophoresis
GAPDH siRNA Combined 0.5 mA cathodal
iontophoresis and 20 V anodal (or
cathodal) electroporation		 Electrophoresis, electroosmosis,
electro-permeabilization, and
diffusion		 Examine the delivery over 24 hr
a

n ≥ 3 replicates in each experimental condition.