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Model of P2Y2R membrane distribution and its regulation by agonists. UTP-mediated activation of the P2Y2R induces transactivation of the EGFR, leading to vessel contraction (A.1) in turn, the EGFR retrotransregulates the membrane distribution of the P2Y2R through a mechanism involving RhoA and Rac1 GTPases, and actin cytoskeleton remodeling (A.2). Under high UTP concentration, the P2Y2R is rapidly internalized, avoiding excessive P2Y2R signaling (B).
