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Intracellular alkalinization attenuates matriptase activation caused by the NHE blockage. 184 A1N4 cells were treated with 20 mm trimethylamine (TMA) along with 50 μm MIBA (lane 3), a NHE potent inhibitor, for 2 h. Untreated cells (lane 1) and cells treated with 50 μm MIBA alone (lane 2) were used as experimental controls. Cell lysates (upper panels) and culture media (lower panel) were collected and analyzed by immunoblotting for total matriptase, activated matriptase, and HAI-1.
