TABLE 3.

CDR homology of light chain variable regions (L1, L2, and L3), and heavy chain variable regions (H1, H2, and H3)

CDR residues contacting the antigen are highlighted in boldface, and CDR3 of 12A11 VH domain displays unique 3- to 5-residue deletions relative to the other antibodies shown.

Antibody	L1	L2	L3	H1	H2	H3
12A11	24RSSQNIIHSNGNTYLE	55KVSNRFS	94FQSSHVPLT	31TSGMSVG	52HIWWDDDKYYNPSLKS	100RTTT-----ADYFAY
10D5	RSSQNIIHSNGNTYLE	KVSNRFS	FQGSHVPLT	TSGMGVS	HIYWDDDKRYNPSLKS	RPITPVL--VDAMDY
12B4	RSSQNIVHSNGNTYLE	KVSNRFS	FQGSHVPLT	TNGMGVS	HIYWDEDKRYNPSLKS	RRIIYDV--EDYFDY
PFA1	RSSQSIVHSNGNTYLE	KVSNRFS	FQGSHVPLT	TSGMGVG	HIWWDDDKSYNPSLKS	RAHTTVL--GDWFAY
PFA2	RSSQSIVHSNGNTYLE	KVSNRFS	FQGSHVPLT	TSGMGVG	HIWWDDDKNYNPSLKS	RAHNVVL--GDWFAY
WO2	RSSQSIVHSNGHTYLE	QVSTRFS	FQASLVPLT	TSKVGVS	HIYWDDDKRYNPSLES	RGFYGRKYEVNHFDY