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a, CASQ2D307H localizes to the jSR. Isolated cardiac myocytes from CASQ2D307H and WT hearts were immunostained to show CASQ2 localization to the jSR as indicated by the merge with α-actinin (at the Z-line). b, electron micrographs from thin sections of age-matched WT, CASQ2−/− and CASQ2D307H myocardium from 3 hearts per group. T-tubules are shaded yellow and the SR vesicles are green. The electron-dense “clumps” are indicated by arrows.
