FIGURE 6.

β-catenin/TCF-signaling is required for AT2 wound repair after monolayer injury. A, AT2 cells were infected on Day₀ with the respective viral constructs. On Day₂, confluent monolayers were scratched and then photographed at 0- and 24-h time points. Representative images for each infection and time point are shown. B, wound surface area was quantified from the images in A at 0 and 24 h and expressed as the percentage of wound area remaining at 24 h. Bars reflect mean values from three independent experiments ± S.D. The difference between Ad-S37A-β-catenin and Ad-ICAT-GFP infections is considered statistically significant (p < 0.05) using analysis of variance analysis (*).