FIGURE 6.

In PBMCs from C57Bl6 wild-type mice sitosterol and sitostanol induced a Th1 shift, similar as that seen in human PBMCs. This Th1 shift is not seen in PBMCs from TLR2 knock-out mice. Results are shown from pooled samples with four mice in each group. In PBMCs from wild-type mice, an increase in IFNγ production is seen after incubation for 52 h. In contrast, in PBMCs from TLR2 knock-out mice, both sitosterol and sitostanol decreased IFNγ production when compared with carrier control and cholesterol.