Skip to main content
. Author manuscript; available in PMC: 2010 Feb 17.
Published in final edited form as: Nature. 2008 May 28;454(7200):126–130. doi: 10.1038/nature06992

Figure 3. TLS negatively regulates the CBP/p300 HAT-regulated CCND1 gene.

Figure 3

a, CCND1 gene expression from RAW264.7 cells treated with forskolin (Forsk) and TLS siRNA. CTL, control. b, c, Chromatin IP (ChIP) of histone acetylation (AceH3-K9K14) on the CCND1 promoter (b) and CCND1 gene expression (c) in the presence of control or CBP and p300 siRNAs (siCBP/p300). * p<0.01, n=3. d, ChIP with indicated immunoglobulin G (IgG) on the CCND1 promoter upon forskolin treatment. MDM2, control. * p<0.01, n=3. e, ChIP of AceH3 on the CCND1 promoter in the presence of control or TLS siRNA. * p<0.01, n=3. Error bars indicate ± SEM.