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. 2009 Nov 30;285(6):3713–3721. doi: 10.1074/jbc.M109.058446

FIGURE 2.

FIGURE 2.

Disruption of PFKFB3/iPFK2 blunts HFD-induced adiposity. At the age of 5–6 weeks, PFKFB3+/− mice and wild-type littermates were fed an HFD or LFD for 12 weeks. For A, C, and D, data are means ± S.E., n = 6. *, p < 0.05 and **, p < 0.01 HFD-PFKFB3+/− versus HFD-wild-type; †, p < 0.05 LFD-PFKFB3+/− versus LFD-wild-type. A, changes in body weight. B–D, changes in visceral fat content. The sum of epididymal, mesenteric, and perinephric fat mass was estimated as visceral fat content. E, adipose tissue histology. The sections of epididymal fat pad were stained with hematoxylin and eosin.