FIGURE 2.

Overview of the structure of the Sgf11-Sus1 complex (yellow, Sgf11 residues 8–31; blue, Sus1) (A) and comparison with Sus1 bound to Sac3 (red, Sac3 residues 755–788; cyan, Sus1) (B). C, the structures (represented as worm format in the same orientations as A and B) of the two complexes superimposed. Sus1 takes up an articulated helical hairpin fold based on five helices separated by flexible hinges that enables it to bend around the Sgf11 helix. D, the principal interactions between Sus1 (blue) and Sgf11 (yellow), which are somewhat different to those observed between Sus1 (blue) and Sac3 (red) (E, see Ref. 10).